Table 3.
Differentially expressed plasma exosomal proteins in SLE patients versus N‑SLE disease controls
| Gene ID | Accession number | log2FC | p-value | Regulation | Expression location | Subcellular localization | Function |
|---|---|---|---|---|---|---|---|
| MME | P08473 | 4.255 | 0.000 | Up | Widely expressed | Cell membrane | Promoting the hydrolysis of bioactive peptides; Promoting cell proliferation and migration |
| HEXB | P07686 | 2.5 | 0.000 | Up | Widely expressed | Lysosome | Enhancing glucose and lipid metabolism; |
| ANTXR2 | P58335 | 2.883 | 0.000 | Up | Widely expressed | Cell membrane | Enhancing cellular defense against harmful substances；Promoting cell adhesion and migration |
| ARHGDIB | P52566 | 2.655 | 0.000 | Up | Widely expressed | Cytoplasm | Inhibiting cell migration and proliferation；Promoting cytoskeletal remodeling |
| FAP | Q12884 | 4.493 | 0.001 | Up | Fibroblast and CAF | Cell membrane | Promoting tissue repair；Promoting tumor progression and metastasis |
| KPRP | Q5T749 | 6.431 | 0.006 | Up | Keratinocyteand air follicle | Cytoplasm | Promoting skin barrier function; Promoting cell proliferation and exert antioxidant effects |
| POSTN | Q15063 | 1.087 | 0.014 | Up | Widely expressed | ECM | Promoting cell adhesion, migration and proliferation；Promoting inflammation and tumorigenesis |
| PSMD6 | Q15008 | 1.659 | 0.029 | Up | Widely expressed | Cytoplasm | Promoting protein degradation; Promoting cell cycle progression |
| CD36 | P16671 | 2.38 | 0.034 | Up | Macrophage、Endothelial cell and Adipocyte | Cell membrane | Promoting the uptake of triglycerides and cholesterol; Promoting inflammatory response and immune modulation |
| PRDX6 | P30041 | 3.091 | 0.045 | Up | Widely expressed | Cell membrane and Cytoplasm | Protecting cells from oxidative stress；Promoting cell signaling |