Sumoylation sites in various transcriptional regulators. Black boxes indicate sumoylation sites. The synergy control motifs (SC), negative regulatory domains (NRD) and repression domains (RD) are underlined. Other characterized domains are indicated with the following abbreviations: DBD, DNA-binding domain; LBD, ligand-binding domain; HLH, helix–loop–helix; Gln, rich in glutamine; AD, activation domain; bZIP, basic zipper; Bromo, bromodomain; HAT, histone acetyl transferase; ZF, zinc finger. Sequence alignments of sumoylation sites are indicated for each protein. h, human; m, mouse; GR, glucocorticoid receptor; AR, androgen receptor; PR, progesterone receptor; C/EBP, CCAAT/enhancer-binding protein; BKLF, basic krüppel-like factor; TRPS1, tricho-rhino-phalangeal syndrome type I.