TABLE 1.
Summary of mitochondrial morphology observed in diseased fibroblasts.
| Mitochondrial morphology | Fibroblast (differentiated/individual cells) | |||
|---|---|---|---|---|
| SBG2‐FB | SBG3‐FB | SBG4‐FB | SBG5‐FB | |
| Skeletal area | ↓ (<0.0001) | ↓ (<0.0001) | ↓ | ↑ |
| Punctuate count | ↑ | ↑ | ↑ | ↑ |
| Rod count | ↑ | ↑ | ↑ | ↑ |
| Network count | ↑ | ↑ | ↓ | ↑ |
| Mean network branch count | ↓ (<0.0001) | ↓ (<0.0001) | ↓ (0.0047) | ↓ |
| Mean rod length | ↓ (0.0004) | ↓ (<0.0001) | ↓ (0.0363) | ↓ (0.0341) |
| Mean Network length | ↓ (<0.0001) | ↓ (<0.0001) | ↓ | ↓ |
| Mean length of all branches | ↓ (0.0011) | ↓ (<0.0001) | ↓ (0.0094) | ↓ |
| Total network branch count | ↓ (<0.0001) | ↓ (0.0006) | ↓ | ↑ (0.0457) |
| All branch count | ↓ (0.0011) | ↓ (0.0029) | ↓ | ↑ |
| Punctuate percentage | ↓ | ↑ | ↓ | ↑ |
| Rod percentage | ↑ (0.0269) | ↓ | ↑ | ↓ |
| Network percentage | ↓ | ↓ | ↓ | ↑ |
| Mean network branch length | ↓ (0.005) | ↓ (0.0003) | ↓ (0.0159) | ↓ |
| Mean network and rod length | ↓ (<0.0001) | ↓ (<0.0001) | ↓ (0.0029) | ↓ |
Note: Comparison of mitochondrial morphology parameters obtained from MitoCellPhe of the diseased fibroblast cells in comparison to the control cell line (BJ‐FB) under basal conditions. ↑↓ means increase or decrease in value. p‐values are noted in parenthesis.