TABLE 2.
Summary of mitochondrial morphology observed in diseased iPSCs.
| Mitochondrial morphology | Induced pluripotent stem cells (undifferentiated/ cluster cells) | |||
|---|---|---|---|---|
| SBG2‐hiPSC | SBG3‐hiPSC | SBG4‐hiPSC | SBG5‐hiPSC | |
| Skeletal area | ↑ (<0.0001) | ↓ (<0.0001) | ↑ | ↑ |
| Punctuate count | ↑ (0.0054) | ↓ (<0.0001) | ↓ (<0.0001) | ↓ |
| Rod count | ↑ (0.0017) | ↓ (<0.0001) | ↓ (0.0014) | ↑ |
| Network count | ↑ (0.0003) | ↓ (<0.0001) | ↓ (<0.0001) | ↓ |
| Mean network branch count | ↑ | ↑ | ↑ (<0.0001) | ↑ (0.0002) |
| Mean rod length | ↓ (0.0284) | ↓ (0.0401) | ↑ (<0.0001) | ↑ |
| Mean Network length | ↓ | ↑ | ↑ (<0.0001) | ↑ (0.0003) |
| Mean length of all branches | ↓ | ↓ | ↑ (<0.0001) | ↑ (0.0192) |
| Total network branch count | ↑ (<0.0001) | ↓ (<0.0001) | ↓ | ↑ |
| All branch count | ↑ (<0.0001) | ↓ (<0.0001) | ↓ | ↑ |
| Punctuate percentage | ↑ | ↑ | ↓ (0.0016) | ↓ |
| Rod percentage | ↑ | ↓ | ↑ (0.0002) | ↑ |
| Network percentage | ↓ | ↑ | ↓ | ↓ (0.0423) |
| Mean network branch length | ↓ | ↓ | ↑ (<0.0001) | ↑ (0.0072) |
| Mean network and rod length | ↓ | ↑ | ↑ (<0.0001) | ↑ (0.0015) |
Note: Comparison of mitochondrial morphology parameters obtained from MitoCellPhe of the diseased undifferentiated hiPSCs in comparison to the control BJ‐hiPSC cell line under basal conditions. ↑↓ means an increase or decrease in value. p‐values are noted in parentheses.