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Proposed mechanism for transient unwrapping of histone-bound DNA and transcription factor binding (adapted from Widom, 2001). Stochastic unwrapping of DNA from one exit/entry point (E) can result in the exposure of a binding site (white box) for a sequencespecific DNA-binding protein. This model suggests one mechanism by which HMGB proteins (blue) might facilitate transcription factor (TF) binding. X indicates the nucleosome dyad.
