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Inhibition of minus-strand “strong-stop” DNA synthesis by SP2 and SP12. Radiolabeled ODN/RNA1-311 complex (10 nM) was extended with 30 nM HIV-1 RNase H− RT. DNA synthesis was performed in the absence (no inhibitor [inh.]) or presence of 1 μM, 10 μM, or 100 μM of SP 2 or SP12 for 0 or 30 s or 1, 5, 10, 20, or 30 min. The minus-strand (−) strong-stop product is labeled, and the pausing sites are indicated by asterisks.
