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Inhibition of HIV-1 replication (IC50) and cytotoxicity (CC50) of selected SP compounds on CEM-SS and MT-4 cell lines
| Inhibitor | HIV-1 LAI/CEM-SS
|
HIV-1 IIIB/MT-4
|
||
|---|---|---|---|---|
| IC50 (μM) | CC50 (μM) | IC50 (μM) | CC50 (μM) | |
| SP1 | 39 | 64 | >CC50 | 30 |
| SP2 | 3 | 7 | >CC50 | 3 |
| SP3 | 3 | 11 | >CC50 | 3 |
| SP4 | 5 | 9 | >CC50 | 5 |
| SP5 | 10 | 20 | >CC50 | 8 |
| SP7 | 6 | 7.5 | >CC50 | 43 |
| SP9 | 3 | 6 | >CC50 | 5 |
| SP10 | 40 | 48 | >CC50 | 29 |
| SP12 | 5 | 7 | >CC50 | 6 |
| SP15 | 0.3 | 9 | >CC50 | 3 |
| AZTa | 0.004 | 0.01 | ||
AZT, zidovudine.
