TABLE 3.
Combination indices for vicriviroc and other antiretrovirals at various inhibitory concentrations against HIV R5-01
| Druga | EC50 | EC75 | EC90 | EC95 |
|---|---|---|---|---|
| Zidovudine | 0.75 ± 0.20b | 0.58 ± 0.12 | 0.45 ± 0.07 | 0.37 ± 0.05 |
| Lamivudine | 0.73 ± 0.04 | 0.62 ± 0.03 | 0.56 ± 0.11 | 0.53 ± 0.16 |
| Efavirenz | 1.18 ± 0.03 | 0.98 ± 0.20 | 0.84 ± 0.32 | 0.76 ± 0.37 |
| Indinavir | 0.97 ± 0.02 | 0.88 ± 0.08 | 0.82 ± 0.11 | 0.80 ± 0.13 |
| Enfuvirtide | 0.94 ± 0.13 | 0.73 ± 0.06 | 0.60 ± 0.03 | 0.53 ± 0.06 |
a
Concentrations of vicriviroc ranged from 0.03 to 1.8 nM; zidovudine from 1 to 16 nM; lamivudine from 0.02 μM to 2.16 μM; efavirenz from 0.3 to 6.0 nM; indinavir from 5 to 72 nM; and enfuvirtide from 1 to 18 nM.
b
Combination index (CI) of <0.9 indicated synergy, between 0.9 and 1.1 indicated near additivity, and >1.1 indicated antagonism. Values represent the mean (±standard deviations) CI from two to four independent experiments.