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A pharmacokinetic profile that approximates free (non-protein-bound) drug concentrations that result from once-daily administration of 500 mg levofloxacin to human subjects (dashed line) is depicted. The solid line describes an equivalent levofloxacin exposure (the same AUC24) under conditions of monkey and murine pharmacokinetics. The datum points (circles and squares) represent the experimentally attained levofloxacin concentrations in the hollow-fiber infection model.
