TABLE 3.

Effects of TPV, RTV, and TPV-RTV on LOP pharmacokinetics^a

PK parameter	LOP alone (n = 24), day 1		LOP-TPV (n = 12), day 9		LOP-RTV (n = 11), day 9		LOP-TPV-RTV (n = 24), day 22
	LOP	LOP metabolite	LOP	LOP metabolite	LOP	LOP metabolite	LOP	LOP metabolite
Cmax (ng/ml)
Geometric mean	3.2	5.5	1.4	1.9	5.5	5.3	1.2	1.1
% Change			↓58	↓66	↑83	↓1	↓61	↓79
Range			0.29-0.62	0.27-0.43	1.23-2.73	0.78-1.25	0.31-0.48	0.17-0.25
AUC0-∞ (ng · h/ml)
Geometric mean	58.3	227.4	22.0	64.4	121.1	309.8	28.8	51.9
% Change			↓63	↓72	↑121	↑44	↓51	↓77
Range			0.27-0.51	0.23-0.33	1.53-3.19	1.00-2.09	0.40-0.61	0.19-0.27
CL/F (liters/h)
Geometric mean	275		728		132		556
% Change			↑264		↓52		↑202

^aData are expressed as geometric mean; comparisons expressed as the geometric mean difference and 90% confidence intervals about the ratio. No effect is a 0% change and a 90% confidence interval encompassing 1.00.