TABLE 2.
Antimalarial activity against Plasmodium berghei
| Compound no. or drug | Oral dose(s) (mg/kg/day) | No. of mice that died/day of death | No. of mice alive on day 31/total no. of mice |
|---|---|---|---|
| 1 | 40 | 1/15, 1/16 | 3/5 (toxic) |
| 20, 10, 2.5, and 1.25 | None | 5/5 | |
| 2a | 80, 40, 20, 10, and 2.5 | None | 5/5 |
| 1.25 | 1/24, 1/27a | 3/5 | |
| 2b | 80, 40, 20, 10, 2.5, and 1.25 | None | 5/5 |
| 3a | 440 | 2/12, 1/14, 2/15 | 0/5 (toxic) |
| 330 | 1/12, 2/14, 2/16 | 0/5 (toxic) | |
| 220, 120, 40, 10, 2.5, and 0.625 | None | 5/5 | |
| 3b | 220, 120, 40, and 10 | None | 5/5 |
| 2.5 and 0.625 | Death in each groupa | 4/5, 3/5 | |
| 3c | 80 | 2/8, 1/9 | 2/5 |
| 40, 20, and 10 | Death in each groupa | 0/5 | |
| 4 | 320 | 3/16, 1/17 | 1/5 |
| 160, 80, and 40 | None | 5/5 | |
| 20 and 10 | Death in each groupa | 2/5, 1/5 | |
| 5 | 160 | 1/11, 1/12, 1/13, 1/14 | 4/8b |
| 80, 40, 20, and 10 | None | 8/8 | |
| Mefloquine | 256 | 1/7, 1/10 | 3/5 (toxic) |
| 128, 64, and 32 | None | 5/5 | |
| 16 | 1/18, 1/19a | 3/5 | |
| 4 | 1/13, 1/18, 1/19a | 2/5 | |
| 2 | 2/18, 1/21, 1/25a | 1/5 | |
| 1 | 3/10, 1/11, 1/22a | 0/5 |
a
Death due to malaria.
b
Separate test (eight mice per dose group).