TABLE 3.

Summary of covariate population pharmacokinetic models tested for CL and V as proposed by generalized additional modeling^a

Model	Covariate(s) of CL	Covariate of V	Decrease in OFVb	Improvement
Basic
Full	GA, age, DAMB	DAMB
Backward	Age, DAMB	DAMB	−5.82	No
exclusion	DAMB	DAMB	−6.33	No
		DAMB	−5.59	No
	DAMB		−1.91	No

^aFor all models, WT^0.75 is a covariate of CL and WT¹ is a covariate of V. Residual variability was modeled using an additional-error model; interindividual variability was modeled using an exponential model. GA, gestational age; age, age at baseline; DAMB, prior treatment with DAMB.

^bDecrease in the objective function value (OFV) compared with that of the hierarchically preceding covariate model.