TABLE 3.
Antimicrobial MICs of A and B homologs of SP508 and SP22
| Organism | MIC (μg/ml) ofa:
|
|||
|---|---|---|---|---|
| SP508A | SP508B | SP22A | SP22B | |
| M. smegmatis ATCC 14468 | 31.25 | 62.5 | 7.8 | 31.25 |
| S. aureus ATCC 6538 | 7.8 | 21.8b | 3.9 | 31.25 |
| B. megaterium ATCC 14381 | 15.6 | 31.25 | 7.8 | 31.25 |
| E. coli ATCC 25922 | >250 | >250 | >250 | >250 |
| P. vulgaris ATCC 13315 | >250 | >250 | >250 | >250 |
| P. aeruginosa ATCC 15442 | >250 | >250 | >250 | >250 |
| Serovar Typhimurium ATCC 14028 | >250 | >250 | >250 | >250 |
| S. marcescens ATCC 8100 | >250 | >250 | >250 | >250 |
| C. freundii ATCC 8090 | >250 | >250 | >250 | >250 |
| R. rubra ATCC 9449 | 3.9 | 2.7b | 1.95 | 7.8 |
| C. albicans ATCC 10231 | 1.95 | 5.4b | 1.95 | 3.9 |
| R. pilimanae | 1.95 | 10.9b | 1.95 | 7.8 |
a
Values were obtained from triplicate determinations. For each determination, the initial SP concentration was 1.0 mg per ml, unless otherwise indicated.
b
The initial SP concentration before twofold serial dilution was 2.8 mg per ml.