TABLE 2.

Main pharmacokinetic parameters of levofloxacin in plasma and pulmonary tissue

Parameter	Patient						Median	Range
	1	2	3	4	5	6
Tmax plasma (min)	20	20	20	40	40	20	20	20-40
Tmax tissue (min)	60	60	40	40	40	40	40	40-60
Cmax plasma (μg/ml)	18.3	17.2	6.7	18.8	11.3	14.5	15.9	6.7-18.3
Cmax tissue (μg/ml)	7.7	10	5	6	10.8	2.2	6.8	2.2-10.8
AUCplasma (μg · h/ml)	44.2	24.3	28.9	37.3	35.9	29.2	32.6	24.3-44.2
AUCtissue (μg · h/ml)	30.6	13.5	11.4	23.7	33.6	10.1	18.6	10.1-33.6
AUCtissue/AUCplasma ratio	0.7	0.6	0.4	0.6	0.9	0.4	0.6	0.4-0.9
AUCtissue/MIC90a ratio	3.8	1.7	1.4	3.0	4.2	1.3	2.4	1.3-4.2

^aThe MIC₉₀ of levofloxacin for P. aeruginosa.