FIG. 2.

Exemplary synthesis of a DAPT compound (1a) starting from 1,3,5-trichloro-triazine (marked by the number 2). Reagents and conditions are as follows: (a) diisopropyl-ethyl amine (ⁱPr₂NEt) and tetrahydrofuran (THF); −25°C, 12 h; (b) ⁱPr₂NEt and THF; 80°C, 48 h; (c) HCl, 1,4-dioxane, and methanol; room temperature, 12 h. Syntheses of anilide (marked by 3) and protected 3,5-diamino-piperidine (marked by 5) as well as those of other DAPT compounds will be reported elsewhere. Boc, tert-butoxycarbonyl.