Skip to main content
. 2005 Dec;79(24):15114–15122. doi: 10.1128/JVI.79.24.15114-15122.2005

TABLE 1.

Level of replication of the HMPV/AMPV chimeras in the upper and lower respiratory tracts of hamsters

Virusa Day of harvest Nasal turbinate
Lung
% with detectable virus Mean titer (log10 PFU/g of tissue ± ME)b Reduction of mean titerc (log10 PFU/g of tissue) % with detectable virus Mean titer (log10 PFU/g of tissue ± ME) Reduction of mean titer (log10 PFU/g of tissue)
rHMPV 3 100 5.4 ± 0.2 100 3.7 ± 0.3
rHMPV-NA 3 83 3.1 ± 0.3d 2.3 66 1.7 ± 0.0d 2.0
rHMPV-PA 3 100 3.6 ± 0.3 1.8 33 1.8 ± 0.1 1.9
AMPV 3 100 5.3 ± 0.1 0.1 83 4.3 ± 0.4
rHMPV 5 100 6.5 ± 0.1 17 1.7 ± 0.0
rHMPV-NA 5 100 5.8 ± 0.2 0.7 50 1.7 ± 0.0
rHMPV-PA 5 100 5.1 ± 0.3 1.4 50 2.1 ± 0.2
AMPV 5 83 3.4 ± 0.3 3.1 67 1.9 ± 0.1
a

Hamsters in groups of 12 were infected intranasally with 105.7 PFU of the indicated virus on day 0.

b

Six animals from each group were sacrificed on days 3 and 5. Nasal turbinates and lungs were harvested, and virus titers were determined by plaque assay. ME, mean error.

c

Reduction of mean log10 titer compared to that of rHMPV.

d

The value of 50 PFU per g of tissue (the lower limit of virus detection) was assigned to animals lacking detectable virus in order to calculate the mean titer.

HHS Vulnerability Disclosure