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. 2005 Dec;79(24):15398–15404. doi: 10.1128/JVI.79.24.15398-15404.2005

FIG. 4.

FIG. 4.

Inhibition of anti-CXCR4 12G5 binding by vMIP-II (A) and (1-10)-vMIP-II-(9-68)-SDF-1α (B) to wild-type CXCR4 and mutants. The data represent the mean values of three independent assays with the error bars indicating the standard deviations. (A) The binding affinity of vMIP-II was decreased by F87A, D97A, Y121A, F292A, and DNX4. (B) Only DNX4 significantly attenuated the binding activity of (1-10)-vMIP-II-(9-68)-SDF-1α. The other mutants had little effect on (1-10)-vMIP-II-(9-68)-SDF-1α binding.