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Long-term IgG antibody response at weeks 12, 24, and 52 after initial immunization with the mutant C(Δ28-89)-S, live, attenuated viruses [3′Δ10847 and C(Δ28-43)], or the formalin-inactivated TBEV vaccine (ImmunInject), as determined by ELISA; bars represent the mean of duplicate assays using pooled sera (n = 4). One group of mice immunized with the replicon C(Δ28-89)-S or with ImmunInject was given a second injection 4 weeks after the initial immunization.
