TABLE 1.
Neutralizing antibody response and protection against virus challenge
| Inoculum | Boostera | NT antibody titer at wk:
|
Protection (no. surviving/no. tested) | Fold increase of IgG titer in surviving mice after challenge | |
|---|---|---|---|---|---|
| 8 | 52 | ||||
| RNA vaccine | |||||
| C(Δ28-89)-S | − | 10 | 15 | 4/4 | 32 |
| C(Δ28-89)-S | + | 80 | 30 | 4/4 | 1.5 |
| Live virus | |||||
| C(Δ28-43) | − | 60 | 20 | 4/4 | 3 |
| 3′Δ10847 | − | 15 | 10 | 4/4 | 2 |
| Killed vaccine | |||||
| ImmunInject | + | 20 | 20 | 4/4 | 0 |
| Control | |||||
| Mock | − | <10 | <10 | 0/4 | NDb |
a
+, mice were given a second injection 4 weeks after the first immunization; −, no booster immunization.
b
ND, not determined because no survivors after challenge.