TABLE 2.
Isotypes of TBEV-specific antibodies
| Inoculum | Boostera | TBEV-specific antibody titer
|
Bias of T-helper responseb | ||
|---|---|---|---|---|---|
| IgG1 | IgG2a | IgG1/IgG2a | |||
| RNA vaccine | |||||
| C(Δ28-89)-S | − | <100 | 800 | 1:>8 | Th1 |
| C(Δ28-89)-S | + | 800 | 6,400 | 1:8 | Th1 |
| C(Δ28-89) | − | 400 | 1,600 | 1:4 | Th1 |
| Live virus | |||||
| C(Δ28-43) | − | 100 | 3,200 | 1:32 | Th1 |
| 3′Δ10847 | − | <100 | 3,200 | 1:>32 | Th1 |
| Killed vaccine | |||||
| ImmunInject | + | 12,800 | 800 | 16:1 | Th2 |
a
+, mice were given a second injection 4 weeks after the first immunization; −, no booster immunization.
b
The type of Th response was assigned based on the IgG subclasses of TBEV-specific antibodies.