Table 2. Genes differentially expressed between wild-type and PPARα-null mice in fasted (top list) and fed (bottom list) state according to microarray analysis.
Fold D., fold difference; FXR, farnesoid X receptor; RIP14, receptor-interacting protein 14; ss, single-stranded.
| Accession no. | Gene | Fold D. | Avg Dif | Function |
|---|---|---|---|---|
| X69296 | Fatty acid ω hydroxylase (CYP4A10) | 56.5 | 120.4 | Fatty acid oxidation/ketogenesis |
| X95280 | G0S2 | 9.2 | 152.6 | Unknown |
| M13366 | NAD-linked GPDH | 7.5 | 167.2 | Glycerol metabolism |
| U14390 | Aldehyde dehydrogenase 3 | 7.4 | 371.9 | Biotransformation |
| U12791 | HMG-CoA synthase (hydroxymethylglutaryl-CoA synthase) | 7.3 | 1490.1 | Fatty acid oxidation/ketogenesis |
| Z14050 | Dodecenoyl-CoA δ isomerase | 5.5 | 423.5 | Fatty acid oxidation/ketogenesis |
| X89998 | 17β-Hydroxysteroid dehydrogenase type IV | 5.2 | 494.7 | Steroid metabolism |
| L11163 | Short-chain-acyl-CoA dehydrogenase | 5 | 208.9 | Fatty acid oxidation/ketogenesis |
| U01163 | Carnitine palmitoyltransferase II | 4.1 | 505.3 | Fatty acid oxidation/ketogenesis |
| U60987 | FAD-linked GPDH | 4.1 | 172.8 | Glycerol metabolism |
| L40406 | Heat-shock protein 105 kDa β | 4 | 150.8 | Heat-shock protein |
| X74938 | HNF3γ (hepatic nuclear factor 3γ) | 3.5 | 103.2 | Transcription factor |
| J03398 | ABC-B4 (ATP-binding cassette B4) (mdr2) | 3.4 | 642.2 | Transporter |
| M22432 | Protein synthesis elongation factor Tu | 3.3 | 186.9 | Protein synthesis |
| L05439 | Insulin-like growth factor-binding protein 2 | 3.2 | 2083.7 | Plasma-binding protein |
| X85983 | Carnitine acetyltransferase | 3.2 | 424.5 | Fatty acid oxidation/ketogenesis |
| U41497 | Very-long-chain-acyl-CoA dehydrogenase | 3.1 | 659.1 | Fatty acid oxidation/ketogenesis |
| U58883 | CAP (c-Cbl-associated protein) | 3 | 158.8 | Insulin signalling |
| X78709 | NRF1 (nuclear respiratory factor 1) | 2.9 | 144.8 | Transcription factor |
| U09010 | Mannose-binding protein A (Mbl1) | 2.9 | 577.2 | Immune function? |
| X98848 | 6-Phosphofructo-2-kinase/fructose 2,6-bisphosphate | 2.8 | 115.2 | Glucose metabolism |
| U33557 | Folylpolyglutamate synthetase | 2.6 | 275 | Folate metabolism |
| J02652 | Malate NADP-oxidoreductase (malic enzyme) | 2.6 | 158.2 | Fatty acid synthesis |
| U44389 | NAD-dependent 15-hydroxyprostaglandin dehydrogenase | 2.5 | 244.7 | Eicosanoid metabolism |
| AA120387 | Mitochondrial Lon protease holomogue 1 precursor | 2.5 | 535.4 | Unknown |
| AA016431 | E-FABP (epidermal fatty-acid-binding protein) | 2.5 | 157.2 | Fatty acid binding |
| U02098 | Pur-α | 2.5 | 122.2 | ssDNA-binding protein |
| U09416 | Bile acid receptor (BAR) (FXR, RIP14) | 2.5 | 505.7 | Transcription factor |
| Y00309 | Lactate dehydrogenase A | 2.4 | 4506.4 | Glucose metabolism |
| U15977 | Long-chain-acyl-CoA synthetase | 2.4 | 1214.7 | Fatty acid activation |
| U15977 | Long-chain-acyl-CoA dehydrogenase | 2.4 | 301 | Fatty acid oxidation/ketogenesis |
| Z19581 | Siah-2 protein | 2.4 | 107 | Unknown |
| U41751 | EI24 (etoposide-induced protein 2.4) | 2.3 | 276.5 | Cell growth/apoptosis |
| J05186 | ERp72 (endoplasmic reticulum protein 72 kDa) | 2.3 | 286.5 | Heat-shock protein |
| U48420 | Gluthatione transferase type 2θ class | 2.3 | 809.8 | Biotransformation |
| U57368 | DBI-1 (epidermal growth factor repeat transmembrane protein) | 2.3 | 102.1 | Mitogen signalling? |
| X70887 | p59 immunophilin | 2.3 | 259.9 | Binds heat-shock proteins |
| D49744 | Farnesyltransferase α subunit | 2.2 | 339.9 | Post-translational processing |
| M65255 | Hydrophilic protein KE2 | 2.2 | 130.1 | Unknown |
| X674689 | LRP1 (LDL receptor-related protein 1) | 2.2 | 402.1 | Cholesterol metabolism |
| D29639 | 3-Hydroxyacyl-CoA dehydrogenase | 2.2 | 2020.7 | Fatty acid oxidation/ketogenesis |
| AA028398 | Tubulin β | 2.2 | 107.8 | Cytoskeleton |
| X51971 | Carbonic anhydrase V | 2.1 | 186.7 | Ureagenesis/gluconeogenesis |
| U76832 | Plasma membrane protein syntaxin | 2.1 | 148.3 | Endo-/exo-cytosis |
| U49878 | HMG-CoA lyase (hydroxymethylglutaryl-CoA lyase) | 2.1 | 1933.9 | Fatty acid oxidation/ketogenesis |
| U48403 | Glycerol kinase | 2.1 | 164 | Glycerol metabolism |
| AA068057 | Ras-related protein RAB21 | 2 | 199.8 | Vesicular transport |
| U06837 | β-Hexosaminidase | 2 | 114.6 | Lysosomal enzyme |
| W30496 | Galactokinase | 2 | 139.7 | Galactose metabolism |
| U07159 | Medium-chain-acyl-CoA dehydrogenase | 2 | 2037.1 | Fatty acid oxidation/ketogenesis |
| M13522 | Serum amyloid A isoform 2 | 15.2 | 829.2 | Acute-phase protein |
| M13521 | Serum amyloid A isoform 1 | 11.9 | 1194.9 | Acute-phase protein |
| V00835 | Metallothionein-I | 5.9 | 130.8 | Acute-phase protein |
| M21285 | Stearoyl-CoA desaturase 1 | 3.2 | 2099.9 | Fatty acid desaturation |
| U73037 | Interferon regulatory factor 7 | 2.9 | 101.5 | Transcription factor |
| Z14050 | Dodecenoyl-CoA δ-isomerase | 2.8 | 331.7 | Fatty acid oxidation |
| X64070 | Mannose phosphate receptor 46 | 2.3 | 109.3 | Lysosomal transport |
| M96823 | Nucleobindin (Calnuc) | 2.2 | 296.9 | Ca2+ binding protein |
| U01163 | Carnitine palmitoyl-transferase II | 2.1 | 536.7 | Fatty acid oxidation |
| X07295 | Mitochondrial malate dehydrogenase | 2 | 295.5 | TCA cycle |
| M28666 | Porphobilinogen deaminase | 2 | 663.6 | Haem synthesis |