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. 2026 Apr 25;15(9):781. doi: 10.3390/cells15090781
PDT Photodynamic therapy
TME Tumor microenvironment
ICD Immunogenic cell death
PS Photosensitizer
ROS Reactive oxygen species
EPR Enhanced permeability and retention
DAMPs Damage-associated molecular patterns
ICIs Immune checkpoint inhibitors
DC Dendritic cell
NIR-PIT Near-infrared photoimmunotherapy
COX-2 Cyclooxygenase-2
PACT Photoactivated chemotherapy
HpD Hematoporphyrin derivatives
Ce6 Chlorin e6
HPPH 2-[1-hexyloxyethyl]-2-devinyl pyro pheophorbide-a
NIR Near-infrared
ICG Indocyanine green
HCC Hepatocellular carcinoma
PPa Pheophorbide-a
ZnPc Zinc phthalocyanine
VTP Vascular-targeted photodynamic
NPs Nanoparticles
LDL Low-density lipoprotein
iPDT Interstitial PDT
DNA Deoxyribonucleic acid
BC Breast cancer
MB Methylene blue
DOX Doxorubicin
5-ALA/ALA 5-aminolevulinic acid
SCLC Small-cell lung cancer
AlPc Aluminum phthalocyanine
Hp Hematoporphyrin
PpIX Protoporphyrin IX
PI3K/AKT Phosphoinositide 3-kinase/Protein kinase B signaling pathway
PCI Photochemical internalization
NSCLC Non-small cell lung cancer
ECOG Eastern Cooperative Oncology Group
ECA External carotid artery
CT Computed tomography (or Chemotherapy in some contexts)
mFOLFIRINOX Modified FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin)
CSCs Cancer stem cells
OXPHOS Oxidative phosphorylation
PDP Photodynamic priming
ECM Extracellular matrix
IFP Interstitial fluid pressure
GSH Glutathione
MDSC Myeloid-derived suppressor cell
PGE2 Prostaglandin E2
NSAIDs Non-steroidal anti-inflammatory drugs
VEGF Vascular Endothelial Growth Factor
AIE Aggregation-induced emission
TAAs Tumor-associated antigens
ATP Adenosine triphosphate
CRT Calreticulin
CTL Cytotoxic T lymphocyte
CTLA-4 Cytotoxic T-lymphocyte-associated protein 4
EITC Eosin-5-isothiocyanate
UCNPs Upconversion nanoparticles
UCNP-Ce6-R837 Ce6 and imiquimod (R837) co-loaded upconversion nanoparticles (UCNPs)
NATNgel NIR fluorescent dye-loaded activatable theranostic nanogel
TNF-α Tumor necrosis factor-alpha
PD-L1 Programmed death-ligand 1
HIF-1α Hypoxia-inducible factor 1-alpha
EGFR Epidermal growth factor receptor
HER2 Human epidermal growth factor receptor 2
HNSCC Head and neck squamous cell carcinomas
PIT Photoimmunotherapy
CPS Combined Positive Score
PDT-DC Photodynamically sensitized dendritic cell
ER Endoplasmic reticulum
PNPs Polymeric nanoparticles
NLCs Nanostructured lipid carriers
AuNPs Gold nanoparticles
PDA Polydopamine
pNALs Photoactivable nanoliposomes
Combo-NP Biodegradable fluorescent NIR-II pseudoconjugated polymer nanoparticle
NIR-II Near-infrared II
CA4P Combretastatin A4 phosphate
ICG-Lipo-C&D Liposomally formulated indocyanine green derivative (ICG-Lipo) encapsulating carboplatin and docetaxel (C&D)
GA/RGD-DOX/ICG-Lips Glycyrrhetinic acid (GA)/arginine-glycine-aspartate (RGD)-targeted and doxorubicin (DOX)/indocyanine green (ICG)-loaded Liposomes
GMP Good Manufacturing Practice
DLI Drug-Light Interval
TIL Tumor-infiltrating lymphocytes
TMB Tumor mutational burden
TKI Tyrosine kinase inhibitor
PK Pharmacokinetics
TNBC Triple-negative breast cancer
PDAC Pancreatic ductal adenocarcinoma
DMBA 7,12-dimethylbenz[a] anthracene
PCDD NPs Platelet membrane-coated nanoparticles
QbD Quality by design