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. 2026 Apr 29;17:1837813. doi: 10.3389/fimmu.2026.1837813

Figure 3.

Panel A shows a timeline and diagram of a mouse experiment involving CPR, secukinumab injection, and subsequent inflammation and echo analysis. Panel B presents bar graphs comparing mRNA expression of Cxcl1, Cxcl2, Ccl2, and Ccl7, showing significant increases after CA/CPR and effects of secukinumab. Panel C displays immunofluorescence images of cardiac tissue from Sham and CA/CPR groups treated with isotype or secukinumab, with a graph quantifying positive area percentage. Panel D contains representative echocardiogram images (M-mode and Doppler) for each group. Panel E provides bar graphs of ejection fraction (EF) and fractional shortening (FS), indicating changes after CA/CPR and treatment. Panel F shows bar graphs of E/A ratio and isovolumic relaxation time (IVRT), evaluating diastolic function among groups.

Early inhibition of IL-17A suppresses myocardial inflammation and improves cardiac function in CA/CPR mice. (A) Schematic representation of the experiment design. (B) Relative mRNA expression of chemokines in indicated groups after 3 h post-CA/CPR (n = 6). Data were analyzed by 2-way ANOVA followed by the Bonferroni post hoc test. **P < 0.01; ***P < 0.001. (C) Left panel: Representative immunofluorescence images of Ly6G staining in indicated groups after 3 h post-CA/CPR (n = 4, scale bar = 50 μm). Right panel: Quantification of immunofluorescence staining presented in the left panel (n = 4). Data were analyzed by 2-way ANOVA followed by Bonferroni’s post hoc test. ***P < 0.001. (D) Representative M-mode and PW Doppler-mode echocardiograms of mice in indicated groups after 3 h post-CA/CPR. (E, F) Quantification of EF, FS, E/A ratio and IVRT in indicated groups (n = 6). White arrows indicated E and A waves. Data were analyzed by 2-way ANOVA followed by Bonferroni’s post hoc test. *P < 0.05; **P < 0.01; ***P < 0.001. CA indicates cardiac arrest; CPR, cardiopulmonary resuscitation; EF, ejection fraction; FS, fractional shortening; IL-17, interleukin-17; IVRT, isovolumic relaxation time.