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. 2026 Apr 29;17:1837813. doi: 10.3389/fimmu.2026.1837813

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Copyright © 2026 Yan, Chen, Yuan, Geng, Wan, Fang, Qiao, Wei and Pu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infographic comparing effects of elevated versus inhibited IL-17A after cardiac arrest and CPR. Left panel shows increased IL-17A causing higher chemokines, neutrophil infiltration, brain injury, and myocardial dysfunction. Right panel shows secukinumab reducing IL-17A, thereby lowering these effects and mitigating organ injury. — Proposed model for IL-17A in the pathogenesis of CA/CPR.