Table 6.
Structural comparison between administered and DT-optimized regimens
| Metric | AMICREA-CI | AMICREA-TH |
|---|---|---|
| Matched dosing occasions, n | 76 | 32 |
| Neonates contributing, m | 37 | 14 |
| Dose amount (occasion-level) | ||
| Median %Δdose | 5.8% | 47.7% |
| MAD %Δdose | 23.0% | 30.3% |
| Timing (inter-dose intervals, h; occasion-level) | ||
| Median Δτ | −6.3 | −15.1 |
| Mean Δτ ± SD | −10.0 ± 11.3 | −20.1 ± 16.6 |
| Cumulative exposure (patient-level) | ||
| Median %Δcum | 3.5% | 35.6% |
| MAD %Δcum | 16.6% | 26.4% |
For dose amount and interval metrics, median, MAD, and mean± SD were computed across all occasion-level values {%Δdose,i} and {Δτi}, with i = 1, …, n. For cumulative exposure, median and MAD were computed across patient-level values {%Δcum,k}, with k = 1, …, m.