Table 7.

Clinical characteristics of patients in the three neonatal cohorts

Clinical variables median [range]	AMICREA-CI	AMICREA-TH		CREA-AKITH
	TDM = 3573, n = 709	TDM = 158, n = 56	p-value	sCr = 5444, n = 869	p-value
Gestational age (weeks)	34 [24–42]	38 [35–41]	<0.001	40 [34–43]	<0.001
Postnatal age (days)	2 [1–30]	1.5 [1–11]	<0.001	3 [1–10]	0.014
Current weight (grams)	2102 [385–4650]	3038 [1910–4770]	0.003	3335 [1750–6230]	<0.001
Serum creatinine (mg/dL)	0.87 [0.40–2.87]	0.86 [0.28–2.21]	<0.001	0.76 [0.08–4.10]	<0.001
Blood culture test
Positive	TDM = 498, n = 101	–		–
Negative	TDM = 3075, n = 608	–		–
Comorbidities
Perinatal Asphyxia	–	TDM = 158, n = 56		–
Acute Kidney Injury	–	–		TDM = 908, n = 127
Co-interventions
Therapeutic Hypothermia	–	TDM = 144, n = 55		TDM = 5444, n = 869
Respiratory support	TDM = 2207, n = 442	TDM = 148, n = 54		–
Ventilation	TDM = 1516, n = 310	TDM = 113, n = 43		–
Inotropes	TDM = 603, n = 134	TDM = 65, n = 31		–
Ibuprofen	TDM = 173, n = 47	–		–

The comparisons of continuous variables GA, PNA, BW, and sCr measurements between three datasets are performed using two-sided Mann–Whitney U test. ‘—’ indicates no available TDM measurements.

n neonates per group.