FIG. 8.

A schematic model for the matrix protein import reaction mediated by the shuttling receptor Pex5 and protein import machinery on the peroxisomal membrane. Pex5 initially targets to an 800-kDa complex containing Pex14 and then translocates to a 500-kDa complex comprising RING peroxins. At the terminal step of the protein import reaction, Pex1 and Pex6 catalyze the export of Pex5. The numbers indicate peroxins, where those in parenthesis are introduced from the published findings. In the 800-kDa complexes, 14n designates the Pex14 oligomer.