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. 2005 Dec;25(24):10953–10964. doi: 10.1128/MCB.25.24.10953-10964.2005

FIG. 2.

FIG. 2.

Vascular abnormalities of Ufd2a−/− embryos. (A) Immunohistochemical analysis of UFD2a expression in a wild-type embryo at E10.5. NT, neural tube; HV, heart ventricle. (B and C) Immunofluorescence analysis of UFD2a (green) and platelet endothelial cell adhesion molecule 1 (a marker for endothelial cells; red) in cardiac tissue of a wild-type embryo at E10.5. The boxed region in panel B is shown at higher magnification in panel C. RA, right atrium; RV, right ventricle. (D to I) Gross morphology of wild-type embryos at E12.5 (D) and E13.5 (G), as well as of Ufd2a−/− embryos at E12.5 (E and F) and E13.5 (H and I). Arrows indicate the various regions of hemorrhage apparent in Ufd2a−/− embryos. (J to M) Electron microscopic examination of vascular sections of the yolk sac (J and K) and brain (L and M) from Ufd2a+/+ (J and L) and Ufd2a−/− (K and M) embryos at E11.5. Scale bars, 2 μm.