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Degeneration of Purkinje cells in Ufd2a+/− mice at 13 months of age. (A and B) Hematoxylin-eosin staining of sections of the cerebellum of wild-type (A) or Ufd2a+/− (B) mice. Arrowheads (B) indicate degenerated Purkinje cells. (C and D) Immunohistochemical analysis of Grp78 expression in the cerebellum of wild-type (C) or Ufd2a+/− (D) mice. (E) Electron microscopy of degenerated Purkinje cells in a Ufd2a+/− mouse. Scale bars, 25 μm (A and B) and 1 μm (E).
