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. 2005 Dec;25(24):11073–11088. doi: 10.1128/MCB.25.24.11073-11088.2005

FIG. 8.

FIG. 8.

Robertsonian fusions in tsFT20 cells. A and B. FISH analyses of metaphase chromosome spreads prepared from tsFT20 cells cultured at 33°C (A) and 38°C (B) for 6 weeks. DNAs stained with DAPI are shown in blue, and telomeric repeats revealed by the Cy3-labeled telomeric repeat PNA probe are shown in red. White arrowheads indicate metacentric chromosomes formed by the Robertsonian fusion. Note that no detectable telomeric repeat signal is present at the fusion points. C. Metaphase spreads obtained from indicated cells were scored according to the number of Rb fusions and the number of total chromosomes. D. Frequencies of spreads displaying different numbers of Rb fusions.