TABLE 3.
Selected genes (and descriptions) up-regulated under cadmium stress
| Gene | Fold change | Annotation |
|---|---|---|
| Efflux pumps (Cluster I) | ||
| CC2721 | 21.3 | Outer membrane efflux protein |
| CC2722 | 36 | Metal ion efflux membrane fusion protein, contains HlyD domain |
| CC2723 | 20 | Hypothetical protein |
| CC2724 | 22.8 | Homologous to nccA and czcA |
| CC2725 | 8 | Conserved hypothetical protein |
| CC2726 | 12.4 | Cation transporting P-type ATPase |
| CC2727 | 6 | Conserved hypothetical protein |
| Efflux pumps (Cluster II) | ||
| CC3195 | 3.4 | Outer membrane efflux protein |
| CC3196 | 2.6 | Contains HlyD domain |
| CC3197 | 3 | Cation/multidrug efflux pump, with AcrB/AcrD/AcrF domain |
| Protect against oxidative stress | ||
| CC1777 | 18.9 | Superoxide dismutase (cofactor, Mn2+) (sodA) |
| CC3557 | 2.2 | Superoxide dismutase (cofactor, Fe2+) (sodB) |
| CC1316 | 3.2 | Glutathione S-transferase |
| CC2434 | 2.2 | Glutathione S-transferase |
| CC0062 | 2.4 | Thioredoxin-like protein |
| CC0110 | 2 | Thioredoxin |
| CC3539 | 2.3 | Thioredoxin |
| CC2505 | 2.3 | Glutaredoxin-related protein |
| CC0994 | 2.5 | Peptide methionine sulfoxide reductase |
| CC1039 | 2.3 | Peptide methionine sulfoxide reductase |
| CC0141 | 2.3 | Glutathione synthetase |
| CC0885 | 3.6 | Riboflavin biosynthesis protein (ribD) |
| CC0886 | 4.3 | Riboflavin synthase, alpha subunit (ribE) |
| CC0887 | 4 | GTP cyclohydrolase II (ribAB) |
| CC0888 | 3.6 | Riboflavin synthase, beta subunit (ribH) |
| CC0459 | 4.1 | GTP cyclohydrolase I (tetrahydrofolate biosythesis pathway) |
| Arsenic resistance pathway | ||
| CC1503 | 4.8 | Arsenic reductase (arsC) |
| CC1504 | 4.4 | Transmembrane channel protein |
| CC1505 | 4.4 | Transcriptional regulator (arsR) |
| CC1506 | 9.9 | Arsenic resistant protein (arsH) |
| DNA repair | ||
| CC1428 | 6 | Deoxyribodipyrimidine photolyase, removes cyclobutane-type pyrimidine dimers in DNA |
| CC2590 | 2 | Excinuclease ABC, subunit A |
| Others | ||
| CC0260 | 2.7 | Ribonucleotide reductase, alpha subunit |
| CC3492 | 2.2 | Ribonucleotide reductase, beta subunit |
| CC2129 | 4.5 | NADH:flavin oxidoreductase |