TABLE 1.
Clinical features, HBV viremia, and prevalence of mutations in precore and core promoter regions in different clinical stages of chronic hepatitis B patients
| Characteristic | Asympatomatic carriers (n = 66) | Chronic hepatitis patients (n = 95) | Liver cirrhosis patients (n = 39) | P value |
|---|---|---|---|---|
| Age (yr) | 31.7 ± 10.2 | 36.5 ± 11.3 | 45.3 ± 11.9 | <0.001 |
| Sex (no. of males:no. of females) | 35:31 | 76:19 | 33:6 | <0.005 |
| ALT level (U/liter) | 23.8 ± 9.8 | 186.6 ± 187.1 | 122.8 ± 126.8 | NSa |
| HBV DNA concn (log pg/ml) | 2.4 ± 1.1 | 1.6 ± 1.1 | 0.001 | |
| HAI inflammation score | 6.1 ± 3.6 | 6.4 ± 3.4 | NS | |
| No. (%) of patients infected with HBV: | ||||
| Genotype B | 52 | 65 | 14 | <0.001 |
| Genotype C | 14 (21.1) | 27 (29.3) | 25 (64.1) | |
| T or G1752 | 28 (42.4) | 35 (36.8) | 8 (20.5) | <0.05 |
| C1753 | 0 | 3 (3.2) | 7 (17.9) | <0.001 |
| T1762/A1764 | 11 (16.7) | 32 (33.7) | 34 (87.2) | <0.001 |
| T1766/A1768 | 1 (1.5) | 7 (7.4) | 6 (15.4) | <0.01 |
| T1773 | 8 (12.1) | 4 (4.2) | 1 (2.6) | <0.05 |
| C1799 | 48 (72.7) | 67 (70.5) | 15 (38.5) | <0.005 |
| T1846 | 14 (21.2) | 17 (17.9) | 12 (30.8) | NS |
| C1858 | 7 (10.6) | 2 (2.1) | 1 (2.6) | <0.05 |
| A1896 | 13 (19.7) | 34 (35.8) | 19 (48.7) | <0.005 |
| A1899 | 5 (7.5) | 1 (1.1) | 4 (10.3) | NS |
a
NS, not significant.