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rpoB mutations and resistance to rifamycin derivatives
| Codon (mutation) | Cross-resistance to rifamycin derivativesa |
|---|---|
| 513 (Gly→Leu) (n = 1)b | Rf, Rp, Rb, Rz |
| 516 (Asp→Val) (n = 3) | Rf, Rp |
| 516 (Asp→Tyr) (n = 3) | Rf, Rp |
| 526 (His→Glu) (n = 5) | Rf, Rp |
| 531 (Ser→Leu) (n = 2) | Rf, Rp, Rb, Rz |
Rf, rifampin; Rp, rifapentine; Rb, rifabutin; Rz, rifalazil.
n, number of isolates sequenced.
