TABLE 2.
Inter- and intralaboratory comparisons of retapamulin zone diameter resultsa
| Zone diam (mm) | No. of occurrences of organism in laboratory:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| A | B | C | D | E | F | G | H | Total | |
| S. aureus ATCC 25923 | |||||||||
| 21 | 0 | ||||||||
| 22 | 1 | 1 | |||||||
| 23 | 6 | 2 | 12 | 7 | 27b | ||||
| 24 | 3 | 9 | 11 | 28 | 24 | 75b | |||
| 25 | 21 | 4 | 21 | 3 | 17 | 20 | 8 | 94b | |
| 26 | 36 | 8 | 21 | 20 | 18 | 16 | 119b | ||
| 27 | 20 | 3 | 1 | 32 | 6 | 4 | 66b | ||
| 28 | 17 | 14 | 5 | 5 | 1 | 42b | |||
| 29 | 11 | 19 | 30b | ||||||
| 30 | 21 | 21b | |||||||
| 31 | 5 | 5 | |||||||
| 32 | 0 | ||||||||
| S. pneumoniae ATCC 49619 | |||||||||
| 11 | 0 | ||||||||
| 12 | 4 | 4 | |||||||
| 13 | 28 | 28c | |||||||
| 14 | 26 | 9 | 13 | 19 | 67c | ||||
| 15 | 2 | 19 | 29 | 30 | 1 | 21 | 102c | ||
| 16 | 18 | 6 | 13 | 21 | 10 | 3 | 71c | ||
| 17 | 6 | 11 | 12 | 14 | 6 | 13 | 62c | ||
| 18 | 8 | 1 | 5 | 15 | 4 | 18 | 51c | ||
| 19 | 9 | 19 | 28c | ||||||
| 20 | 6 | 6 | |||||||
| 21 | 1 | 1 | |||||||
| 22 | 0 | ||||||||
Results represent testing of two QC strains for an eight-medical-center protocol meeting the study design guidelines found in CLSI M23-A2 (4).
Proposed QC range (23 to 30 mm) that included 98.8% of reported zone diameters from eight laboratories.
Proposed QC range (13 to 19 mm) that included 97.4% of reported zone diameters from seven laboratories (laboratory H results were omitted from analysis).