TABLE 2.
Bivariate analysis of the association between plc gene genotypes and clinical characteristics using GEE
| plc gene genotype | Clinical characteristic
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Extrathoracic TB involvement (n = 682)
|
Cavitation in the lungs (n = 584)
|
Sputum smear positive (n = 586)
|
|||||||
| No. with TTBa | No. with ETTBb | OR (95% CI) | No | Yes | OR (95% CI) | No. negative | No. positive | OR (95% CI) | |
| plcD genotypes | |||||||||
| plcD wild type | 405 | 44 | 1.00 (referent) | 243 | 144 | 1.00 (referent) | 228 | 162 | 1.00 (referent) |
| plcD mutant | 29 | 9 | 2.86 (1.32-6.19) | 21 | 11 | 0.88 (0.41-1.89) | 22 | 10 | 0.64 (0.30-1.39) |
| plcD and adjacent gene, mutant group | 170 | 25 | 1.35 (0.82-2.23) | 104 | 61 | 0.99 (0.68-1.44) | 85 | 79 | 1.31 (0.91-1.89) |
| plcABC genotypes | |||||||||
| plcABC wild type | 546 | 69 | 1.00 (referent) | 326 | 197 | 1.00 (referent) | 298 | 227 | 1.00 (referent) |
| One of plcABC mutant | 40 | 7 | 1.38 (0.58-3.30) | 28 | 13 | 0.77 (0.40-1.48) | 24 | 17 | 0.93 (0.50-1.74) |
| Two of plcABC mutant | 6 | 1 | 1.32 (0.15-1.68) | 5 | 2 | 0.66 (0.16-2.67) | 5 | 2 | 0.52 (0.13-2.13) |
| plcABC all mutant | 12 | 1 | 0.66 (0.08-5.30) | 9 | 4 | 0.74 (0.27-2.00) | 8 | 5 | 0.82 (0.25-2.66) |
a
TTB, thoracic tuberculosis.
b
ETTB, extrathoracic tuberculosis.