TABLE 5.
Frequently encountered virulence profiles among Escherichia coli isolates from women with cystitis or pyelonephritis and uninfected women
| Profile no.a | Clustera | No. of isolatesb | Phylogenetic group(s)c | Main O group(s)d (no.) | Distribution of isolates by sourcee
|
Constituent gene(s) | ||
|---|---|---|---|---|---|---|---|---|
| Fecal (76) | Cyst (83) | Pyelo (170) | ||||||
| 1 | Ia | 11 | D | O17/O77 (6) | 0 | 1 | 10** | papA/C/EF/G, F16, papG II, iha, fim, iutA, kpsM II, traT, ompT |
| 2 | Ia | 9 | D | O17/O77 (6) | 0 | 6** | 3 | Same as profile 1, plus fyuA |
| 3 | Ia | 22 | B2 | O1/O2 (19) | 9* | 2 | 11 | papA/C/EF/G, F11, papG II, iha, fim, fyuA, kpsM II, K1, traT, ompT, malX |
| 4 | Ia | 6 | B2 | O18 (5) | 0 | 2 | 4 | papA/C/EF/G, F10, papG III, sfa/foc, sfaS, fim, hly, cnf, fyuA, kpsM II, K1, traT, ibeA, ompT, malX |
| 5 | Ib | 5 | B2 | O6 (5) | 1 | 0 | 4 | papA/C/EF/G, F48, papG III, sfa/foc, sfaS, fim, hly, cnf, iroN, fyuA, kpsM II, traT, ompT, malX |
| 6 | Ib | 12 | B2 | O75 (12) | 1 | 0 | 11** | afa/dra, fim, fyuA, iutA, kpsM II, traT, ompT, malX |
| 7 | IIa | 5 | B2 | O75 (4) | 1 | 0 | 4 | Same as profile 6, minus iutA |
| 8 | IIa | 7 | Mult | Mult | 0 | 3 | 4 | fim, fyuA, kpsM II, K1, traT, ibeA, ompT |
| 9 | IIb | 7 | Mult | Mult | 4 | 1 | 2 | fim, ompT |
| 10 | IIb | 5 | Mult | Mult | 2 | 2 | 1 | fim, iroN, fyuA, kpsM II, K1, traT, ibeA, ompT |
| 11 | IIb | 22 | A, B1 | Mult | 6 | 10* | 6(*) | fim |
Pathotypes and clusters were numbered sequentially as encountered in the virulence profile-based tree.
Number of isolates with indicated pathotype.
For pathotypes 1 to 7, all isolates were from the phylogenetic group shown for that pathotype. Pathotypes 8 to 10 were represented by isolates from three or four phylogenetic groups each. Pathotype 11 was represented by 15 group A isolates and 7 group B1 isolates. Mult, multiple groups.
Within pathotypes 1 and 2, 12 isolates expressed either the O17 or O77 antigen (n = 6) or both antigens (n = 6). Additionally, pathotype 2 contained one isolate each that expressed either the O11 or O73 antigen. Mult, multiple O antigens.
Numbers shown in parentheses are total numbers in each source group (fecal, cystitis, pyelonephritis). P value symbols (*, P < 0.05; **, P < 0.01), by Fisher's exact test, are for prevalence of the indicated pathotype within the particular source group versus among all other isolates combined. Symbols shown in parentheses denote negative associations. Cyst, cystitis; Pyelo, pyelonephritis.