Table 3.
Summary of input parameters for the base case model
| Base case | |||
|---|---|---|---|
| PC | CA | ||
| Transition probability (1 cycle = 4 weeks) | |||
| Assumption | No → no insomnia | 1.00 | 1.00 |
| Treatment phase | Severe → no insomnia (remissiona) | 0.50 | 0.00 |
| Severe → mild | 0.30 | 0.67 | |
| Severe → moderate | 0.20 | 0.33 | |
| Moderate → no insomnia (remissiona) | 0.65 | 0.52 | |
| Moderate → mild | 0.27 | 0.32 | |
| Moderate → moderate | 0.08 | 0.16 | |
| Follow-up phase | Moderate → mild | 0.43 | 0.80 |
| Moderate → moderate | 0.57 | 0.20 | |
| Mild → no insomnia (remission) | 0.30 | 0.15 | |
| Mild → mild | 0.57 | 0.77 | |
| Mild → moderate | 0.13 | 0.08 | |
| Medical costs for 4 weeks (KRW) | |||
| Treatment phase (KM and WM) | 481,000 | 403,000 | |
| Follow-up phase (WM) | 6100 | 6200 | |
| Utility | |||
| No insomnia | 0.844 | 0.844 | |
| Mild | 0.791 | 0.791 | |
| Moderate | 0.784 | 0.784 | |
PC, pharmacopuncture; CA, conventional acupuncture (traditional acupuncture and electroacupuncture); KM, Korean medicine; WM, Western medicine
aRemission defined as Insomnia Severity Index score < 8
bTransition probabilities were derived from observed transitions between insomnia severity states across consecutive time points in the clinical trial. No relapse was assumed in the base case analysis
cMedical costs were estimated using trial-based data (PC pricing, WM utilization) and national fee schedules (acupuncture, electroacupuncture, hypnotics, and WM visit costs)
dUtility values were derived from HINT-8 scores using ISI-based severity categories estimated from the clinical trial using a linear mixed-effects model