FIG.4.

Conserved motifs and alignments of the adenylation, condensation, thiolation, epimerization, and reductase domains from the BT NRPS modules. Conserved motifs were identified as described by Marahiel (13). Consensus sequences are indicated under each alignment. Residues that are the same as consensus residues are indicated by a black background. All 12 C-domains were aligned, and asterisks indicate the start C-domains that are known to be less conserved.