Figure 1. Integrated clustering of retroelement methylation identifies three distinct epigenetic.

subtypes in ccRCC

Network-fusion-based Neighborhood-based Multi-Omics Clustering (NEMO) applied to integrated REMP-predicted Alu, LINE-1 (L1), and LTR methylation profiles stratified TCGA-KIRC tumors into three distinct and internally homogeneous subgroups. The Repressed subtype is characterized by globally high retroelement methylation, the Active subtype exhibits widespread hypomethylation consistent with retroelement derepression, and the Transient subtype displays intermediate methylation levels.