Table 2.
Distribution of clinical characteristics across RE-defined subtype
| Groups | Repressed n=171 | Transient n=57 | Active n=80 | p | |
|---|---|---|---|---|---|
| Age, mean (SD) (yrs) | 59.58 (12.08) | 64.49 (11.27) | 62.73 (10.25) | 0.009 | |
| Sex n (%) | Female | 54 (31.6) | 22 (38.6) | 29 (36.2) | 0.56 |
| Male | 117 (68.4) | 35 (61.4) | 51 (63.7) | ||
| Stage, n (%) | I | 116 (67.8) | 19 (33.3) | 16 (20.0) | <0.001 |
| II | 14 (8.2) | 6 (10.5) | 8 (10.0) | ||
| III | 26 (15.2) | 14 (24.6) | 31 (38.8) | ||
| IV | 15 (8.8) | 18 (31.6) | 25 (31.2) | ||
| Grade, n (%) | G1 | 6 (3.5) | 1 (1.8) | 0 (0.0) | <0.001 |
| G2 | 94 (55.0) | 22 (38.6) | 17 (21.2) | ||
| G3 | 59 (34.5) | 24 (42.1) | 36 (45.0) | ||
| G4 | 12 (7.0) | 10 (17.5) | 27 (33.8) |
The Repressed group is enriched for early-stage and lower-grade tumors, whereas the Transient and Active subtypes show higher proportions of advanced-stage disease and high-grade tumors. Age diLered significantly across subtypes (one-way ANOVA, p = 0.009), while sex distribution did not diLer (chi-square test). Tumor stage and grade were strongly stratified across RE subtypes (chi-square tests, both p < 0.001.