Table 3.

Summary of hazard ratios, 95% confidence intervals, and p values for the Active subtype across multivariable Cox models.

Models	Covariates	HR	95% CI	P value
Model 1a	Age, Sex, Stage	1.85	1.15-2.98	0.0114
Model 1b	Model 1a + TME	1.81	1.10-2.97	0.020
Model 2a	Age, Sex, AUA Risk	1.94	1.21-3.12	0.0060
Model 2b	Model 2a +TME	1.93	1.17-3.17	0.0095

Hazard ratio estimates remain consistent with and without adjustment for tumor microenvironment features, supporting an independent association between the Active RE methylation subtype and worse overall survival.