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Comparison of viral titers in the eyes (A) and the number of lytic viral protein-expressing neurons in the TGs (B) of mice infected with 17/tBTKR (triangles) and 17/tBTK− (squares) at 48 h p.i. Open symbols indicate groups of mice treated with ACV as detailed in Materials and Methods (+ACV). The difference in the number of lytic protein-positive neurons in TGs of 17/tBTKR- and 17/tBTK−-infected ganglia was significant (P = 0.028, Student's t test).
