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. 2006 Jan;80(1):192–200. doi: 10.1128/JVI.80.1.192-200.2006

FIG. 2.

FIG. 2.

IFN-γ-mediated inhibition of γHV68 reactivation is neutralizable by anti-IFN-γ antibody early after explantation. Ex vivo reactivation is shown. The statistical difference between medium and plates with 10 U of IFN-γ/ml is P < 0.0001. PIP-treated plates were not statistically different from IFN-γ plates on any day. H22-treated plates were statistically different from IFN-γ plates at days 1, 2, 3, and 5 with the following P values: P = 0.03, P = 0.04, P = 0.05, and P = 0.05, respectively. At day 4, the difference between H22-treated plates and IFN-γ plates was not significant (P = 0.07). The capacity of neutralizing antibody to inhibit reactivation waned over time. By day 8, the ability to neutralize IFN-γ with H22 was lost. the statistical difference between day 1 H22-treated plates and day 8 H22-treated plates was significant at P = 0.01. n, number of independent experiments.