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. 2006 Jan;80(1):181–191. doi: 10.1128/JVI.80.1.181-191.2006

FIG. 1.

FIG. 1.

Schematic diagrams of the HTLV-2 genome and the different mRNAs (horizontal lines) and proteins (gray boxes) (A). Dashed lines represent introns that are spliced out. Below (panel B) are the different Tax expression plasmids used in this study. wtHTLV-2 and BCHTLV-2 are full-length proviral clones that express doubly spliced tax/rex mRNA. IY619 and Tax-2 (BC20.2) express the entire tax/rex coding sequence as a cDNA but lack the 5′UTR. IY620 and IY531 express full-length tax/rex cDNA, which includes the 5′UTR. IY587 is a proviral clone with truncated intron-1 (gag/pol sequences) that still expresses doubly spliced tax/rex mRNA. IY594 expresses tax/rex mRNA lacking the 5′UTR but contains intron-2. Both IY588 and IY595 express full-length tax/rex mRNA that contains a truncated intron-1 (gag/pol sequences) or intron-2 (env sequences), respectively. For more detailed description of the plasmids, see Materials and Methods. Plasmids wtHTLV-2, IY619, IY620, and IY587 express tax/rex mRNA from the HTLV-2 promoter (LTR), whereas plasmids BCHTLV-2, Tax-2, IY531, IY588, IY594, and IY595 utilize the CMV immediate early promoter. Asterisks represent Rex and Tax start codons.