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A model for the mechanism of action of p28II. After recruitment to the HTLV-2 promoter in a Tax-dependent manner, p28II associates with RNA Pol II and moves with the transcription elongation machinery. As the RNA is being synthesized, capped, and spliced, a novel mRNA element is generated (possibly the exon-2-exon-3 junction only present in tax/rex mRNA) and is recognized by p28II, which translocates to the mRNA, leading to its retention in the nucleus.
