FIG. 4.

Changes in soluble factor-mediated CD8⁺ cell-derived antiviral activity with time after infection. The ability of CD8⁺ supernatants at a 1:5 dilution to inhibit SIVmac replication in CD4⁺ T cells was tested. Differences in the level of inhibition from baseline (net difference from baseline) were calculated by subtracting the percent suppression measured at baseline from the percent suppression measured at each time point and are shown separately for each macaque of group 1 (A), group 2 (B), and group 3 (C). At the top of each graph, at each time point, a “+” is marked if viral replication was inhibited by ≥50% and a “−” indicates the percent suppression was <50%. †, Death of the animal.