TABLE 1.
Genes activated by both heat and acid in JRS4
| Locusa | Description (gene)b | Time after shift (min)c
|
|
|---|---|---|---|
| Acid | Heat | ||
| SPy0024 | Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC) | 5, 10 | 5 |
| SPy0025 | Phosphoribosylformylglycinamidine synthase | 5 | 5 |
| SPy0033 | Phosphoribosylaminoimidazole carboxylase (purE) | 10 | 5 |
| SPy0229* | ABC transporter, ATP-binding protein, putative | 5, 10 | 5 |
| SPy0230* | Transport ATP-binding protein, putative | 5, 10 | 5 |
| SPy0570* | Drug transporter, putative | 5, 10, 20 | 5 |
| SPy1135 | GMP reductase (guaC) | 5, 10 | 5 |
| SPy1136 | Xanthine phosphoribosyltransferase (xpt) | 5, 10, 20 | 5, 10 |
| SPy1159 | Predicted membrane protein, hemolysin, putative (hly) | 5 | 5 |
| SPy1216 | Domain of unknown function, putative | 5 | 5 |
| SPy1284 | DNA polymerase III, alpha subunit (dnaE) | 5 | 5 |
| SPy1404* | Hypothetical protein | 10 | 5 |
| SPy1406 | Superoxide dismutase (sodA) | 5, 10, 20 | 5 |
| SPy1746 | (3R)-hydroxymyristoyl-(acyl carrier protein) dehydratase (fabZ) | 20 | 10 |
| SPy2080 | Putative NADH oxidase (nox1) | 10, 20 | 10 |
a
Locus is listed for GAS M1 strain SF370. Genes with an * represent the genes found to be CovR repressed in JRS4 (this study). Loci in boldface type represent genes previously found by Graham et al. to be CovR repressed in MGAS5005 (21).
b
Description is the proposed function as annotated by TIGR or by sequence homology identified by BLASTP analysis.
c
Times after the shift to the stress condition at which the gene is activated.