FIG. 1.

Predicted structure of the EmhB efflux pump, modeled using the known crystal structure of the E. coli pump AcrB (PDB entry 1IWG [19]). (A) The view of the predicted EmhB trimer from above the plane of the inner membrane shows the presence of a pore extending through the pump. (B) The transmembrane domain (TMD), pore domain, and outer membrane protein docking domain (OMPDD) are indicated on the side view of the EmhB trimer, with the rear monomer removed to facilitate viewing. A central cavity is present at the center of the pump above the transmembrane domain. This figure and Fig. 3, 4, and 5 were drawn using the DS ViewerPro version 6.0 software (Accelrys).