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Effect of inhibition of SIRT1 catalytic activity on cell viability and proliferation following DNA damage in primary human cells. HMEC were treated with increasing concentrations of etoposide or adriamycin in the presence or absence of 1 μM EX-527. (A and C) Cell viability was measured at 48 h; (B and D) cell proliferation at 48 h was measured by monitoring [14C]thymidine incorporation.
