Figure 4. Terminal repeats differ in amino acid composition.

Repeats 2 and 7 are shown end on, looking down the long axis of the domain. The rest of the ANK domain is hidden for clarity. Residues that constitute the helices in these repeats are shown in stick-model form. Coloured red are polar and charged residues, hydrophobic residues are blue, and connecting loops are in white. Selected amino acids are labelled, the numbering referring to the position of residues in the sequence alignment in Figure 1. The hydrophobic core is exposed in repeat 2 (Ala⁶⁰, Ala⁶⁴, Ala⁷² and Leu⁷⁶). In repeat 7, polar and charged residues cover the hydrophobic core (Arg²²⁷ and Asn²³¹). The Figure was created using PyMOL.